Alzheimer’s affects most signaling pathways; the FDA’s ALS plan; Can sensors predict a concussion?

Alzheimer’s disease is linked to most of the biological signaling pathways in the brain, according to an extensive literature review. (Frontiers in aging neuroscience)

Following Medicare’s coverage decision for aducanumab (Aduhelm), Biogen terminated its prospective ICARE AD study, which was designed to collect real-world data about the drug.

The FDA presented its 5-year strategy and plan of action for amyotrophic lateral sclerosis (ALS) and other rare neurodegenerative diseases.

The agency also suspended a clinical investigation of a gene replacement therapy trial for late-onset Pompe disease after a participant developed peripheral sensory neuropathy, Astellas Pharma said.

Midlife hypertension and amyloid beta each independently predicted dementia risk but did not interact significantly. (Annals of Neurology)

Cognitive-behavioral therapy improved disability-related post-traumatic headache in military veterans and improved the severity of post-traumatic stress disorder (PTSD) symptoms. (JAMA Neurology)

COVID-19 mRNA vaccines have been safe in people with myasthenia gravis and have not shown any adverse effects on disease progression. (Neurology: Neuroimmunology & Neuroinflammation)

A flexible sensor patch in the neck can help predict risk of concussion in high-impact sports like American football. (Scientific Reports)

That APÖ4 Allele may confer an increased risk of chronic traumatic encephalopathy (CTE)-related sequelae in older people with repetitive headbutt exposure. (JAMA Neurology)

APÖ4 may also initiate glial-specific cell and non-cell autonomic dysregulation that may contribute to an increased risk of Alzheimer’s. (cell)

Brexpiprazole (Rexulti), a drug approved for schizophrenia and major depressive disorder, reduced agitation in Alzheimer’s patients compared with placebo in a Phase III study, drug companies Lundbeck and Otsuka said.

Virtual reality users could feel additional robotic arms as part of their own body. (Scientific Reports)

The extent of abdominal aortic calcification was associated with dementia 15 years later. (Lancet Regional Health Western Pacific)

Age, creatinine, and glycated hemoglobin predicted serum neurofilament light levels in people without neurological disorders. (Annals of Neurology)

  • Judy George reports on neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headaches, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain and more. consequences

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